Carrier detection of phenylketonuria in Iranian families by variable number tandem-repeat polymorphism analysis
(East. Mediterr. health j).
in En
| WHOLIS
| ID: who-117576
Responsible library:
CH1.1
ABSTRACT
This study of Iranian families assessed the usefulness of carrier detection of phenylketonuria by variable number tandem-repeat [VNTR] polymorphism analysis. We studied 171 people [45 unrelated PKU subjects, and their parents and unaffected siblings]. Of 342 chromosomes [131 non-PKU and 211 PKU], 5 VNTR alleles were identified. This VNTR system would yield a polymorphism information content of 66%, comparable to that in Europeans and higher than in Chinese. Carrier detection by segregation analysis of VNTR was informative in 89.5% of siblings. We conclude that this polymorphism is highly informative in carrier detection of PKU in the Iranian population
Key words
Full text:
1
Collection:
04-international_org
Database:
WHOLIS
Main subject:
Phenylketonurias
/
Polymorphism, Genetic
/
Family
/
Carrier State
/
Polymerase Chain Reaction
/
Tandem Repeat Sequences
Language:
En
Journal:
East. Mediterr. health j
Year:
2008